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KMID : 0376419850090020189
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Chonbuk University Medical Journal
1985 Volume.9 No. 2 p.189 ~ p.194
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Studies on the Hypertension in Experimental Hypertensive Rat
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Abstract
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One of the most powerful factors controlling the renin release has been known as sympathetic regulation. It has been reportedly known that the beta-adrenoceptor in the kidney is responsible for the renin release. There has been reported, however, on the extrarenal beta-adrenoceptor for the renin release.
In order to investigate the possible differences in the mechanism of renin release by betaagonist in spontaneously hypertensive rats (SHR), we did an experiment.
Basal and agonist-induced rate of renin release was suppressed in the SHR compared with normotensive control rats. Both routes of intravenous, and intrarenal arterial infusion of isoproterenol resulted in a dose-dependent renin release. Systemic intravenous infusion of isoproterenol showed higher rate of renin release than the intrarenal arterial infusion in all experimental strain. Intrarenal arterial infusion of isoproterenol showed no differences in renin release between the hypertensive and normotensive rats.
The above data suggest that 1) the extrarenal as well as intrarenal beta-adrenoceptor may be responsible for the renin release by isoproterenol in the SHR, and 2) the mechanism(s) of suppressed responsiveness to isoproterenol for the renin release may be lie not on the renal but on the extrarenal receptor.
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